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KMID : 0043320130360060768
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Archives of Pharmacal Research
2013 Volume.36 No. 6 p.768 ~ p.774
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Oleanane-type triterpenoid saponins from the roots of Pulsatilla koreana and their apoptosis-inducing effects on HL-60 human promyelocytic leukemia cells
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Li Wei
Ding Yan
Sun Ya Nan
Yan Xi Tao
Yang Seo-Young
Choi Chun-Whan
Kim Eun-Ji
Kang Hee-Kyoung
Kim Young-Ho
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Abstract
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Twenty-four oleanane-type triterpenoid saponins were isolated from a methanol extract of the Pulsatilla koreana roots. Their structures were elucidated by comparing spectroscopic data to published values. Among them, compounds 8?12 and 20?24 significantly diminished the proliferation of HL-60 human promyelocytic leukemia cells with IC50 values from 0.3 to 4.2 μM, whereas compounds 7 and 19 showed moderate cytotoxic activity. Furthermore, apoptotic characteristics such as chromatin condensation and increase in the population of sub-G1 hypodiploid cells were observed after the HL-60 cells were treated with these compounds.
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KEYWORD
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Pulsatilla koreana, Ranunculaceae, Triterpenoid saponin, Cytotoxic activity, HL-60 cell, Apoptotic characteristics
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